PMON248 Predictive value of markers of hyperandrogenism in 1610 women with PCOS

Abstract Polycystic ovary syndrome (PCOS), an endocrine disorder that affects 10% of women worldwide. In 1990, the NIH established first consensus on diagnostic criteria for PCOS which included chronic anovulation with clinical and/or biochemical hyperandrogenism, after exclusion related disorders. Traditionally assessment hyperandrogenism serum studies total testosterone (TT), free (FT), and dehydroepiandrosterone sulfate (DHEA-S), physical exam assessing hirsutism using modified Ferriman-Gallwey (mFG) score. The most recent 2018 International Guidelines suggest measurement DHEA-S can be considered if TT or FT are not elevated, but probably provide limited value. We evaluated utility TT, FT, in a large prospective cohort women. Subjects presented to tertiary-care specialty clinics symptoms androgen excess Birmingham, Alabama Los Angeles, California from 1987-2010. Clinical was assessed mFG score, defined as >4. Participants underwent assess hyperandrogenemia exclude other causes hyperandrogenism. Fasting blood samples were obtained cycle days 3 through 8 spontaneous progesterone-induced vaginal bleed DHEA-S. Elevated androgens values exceeding laboratory reference range greater than 95th percentile reported values. have oligomenorrhea they >35 day cycles, <10 bleeds per year being eumenorrheic confirmed non-ovulatory luteal phase progesterone <4 ng/mL. One thousand six hundred ten adolescents (n=1610), aged > 14 years, diagnosed by Criteria included. Of these 1610 subjects, 39.3% (n=643) based upon elevated oligomenorrhea; 23.9% (n=384) normal 11.3% (n=182) 1.1% (n=17) DHEA-S; androgens, oligomenorrhea, (mFG>4). Results diagnosis is rarely made setting FT. Most had values, still significant proportion (23.9%) context androgens. Thus, hirsutism, both timely inexpensive, strong predictor valuable tool diagnosing PCOS, reserving DHEAS when better measures diagnostic. Presentation: Monday, June 13, 2022 12:30 p.m. - 2:30